Non-self-complementary AAV with Mouse U6 Promoter driving a scrambled shRNA control shSafe cassette followed by a second reporter cassette containing the CMV (Cytomegalovirus) Promoter driving EGFP. Please reference: Boudreau, R. L., et al. (2011). "Rational Design of Therapeutic siRNAs: Minimizing Off-targeting Potential to Improve the Safety of RNAi Therapy for Huntington's Disease." Mol Ther 19(12): 2169-2177.
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